Multiple Unit Drug Delivery System: Pelletization Techniques

نویسندگان

  • S. Ramu
  • G. Ramakrishna
  • M. Balaji
  • K. Kondala rao
  • S. Haranadh reddy
  • D. pavan kumar
چکیده

The present study aims at discussing the potential advantages of multiple unit dosage forms (pellets etc.) over the single unit dosage forms (tablets). Pelletization is a novel drug delivery system; a technique which converts fine powder particles into pellets. Review deals with the pellet and its various types of pelletization techniques like spheronization and extrusion, pelletization by layering, pelletiztion by solution layering &direct pelletization.The advantages, disadvantages & various applications of above mentioned techniques.spheronization and extrusion pelletization by layering are most widely used techniques.The study also deals with factors and evaluation of pellets.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CODEN : IJPNL 6 Multi unit drug delivery system – A brief review of pelletization technique

At present time pharmaceutical research and development showing its interest on drug delivery. Which enhances therapeutic action while minimizing side effect. Use of multi-particulate is the gift of that research which achieve delayed or controlled release with low risk of dose dumping, flexibility of blending to attain different release pattern as well as reproducible and short gastric residen...

متن کامل

Pelletization Technique in Drug Delivery System- a Review

In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage f...

متن کامل

Pelletization Technology: a Quick Review

Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sus...

متن کامل

Pelletization Techniques: A Review

Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. This review outlines manufacturing of spherical pellets. The manufacturing techniques include Drug layering, Extrusion-Spheronization, Cryopelletization, Compression, Balling, Hot-Melt Extrusion Technol...

متن کامل

Extrusion Spheronization –A Review

Compared to single-unit dosage forms, oral multiparticulate drug-delivery systems (e.g. pellets, granules) offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastrointestinal tract. There are different pelletization and granulation techniques available to prepare drug loaded spherical particles or granules. Extrusion Spheronization ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013